ONG21001
Rheumatoid Arthritis associated Interstitial Lung Disease; RA-ILD
- Rheumatoid arthritis(RA), a chronic systemic inflammatory disease, has several complications, among which can be RA-ILD.
- RA-ILD has a survival rate of less than 50% within 5 years following diagnosis and the overall prognosis is similar to idiopathic pulmonary fibrosis(IPF).
- To date, no effective treatment has been developed, and standard RA drug or IPF drugs are used as an alternative.
The Mechanism of Action of ONG21001
- ONG21001 acts as an actin depolymerizer and has a mechanism to prevent the activation of TGF-β, a major mediator of fibrosis.
In vivo data
In vivo data
